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BRCA1 antibody

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产品名称: BRCA1 antibody
产品型号:
产品展商: immunoclone
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简单介绍

BRCA1 antibody迅速增长的产品线包括一抗、二抗、**测定及细胞检测试剂盒、蛋白/多肽、激动剂/拮抗剂/活化剂/抑制剂及裂解物等。BRCA1 antibody严格的质量控制和验证实验包括各种不同的应用：WB、细胞**荧光、**组化、流式细胞术、ELISA、CHIP、IP和peptide array。


BRCA1 antibody  的详细介绍

BRCA1 antibodyProduct Profile

Product Name Rabbit anti-BRCA1 polyclonal antibody - N-terminal region
Antibody Type Primary Antibodies
Immunogen 
The immunogen for anti-BRCA1 antibody: synthetic peptide directed towards the N terminal of human BRCA1

BRCA1 antibodyKey Feature

Clonality Polyclonal
Isotype IgG
Host Species Rabbit
Tested Applications

WB

Species Reactivity

DogHumanRat

Concentration 1mg/ml
Purification Affinity purified

BRCA1 antibodyTarget Information

Gene Symbol BRCA1
Gene Synonyms
BRCAI
BRCC1
IRIS
PSCP
RNF53
PNCA4
BROVCA1
PPP1R53
Gene Full Name Breast cancer 1, early onset
Gene Summary
The BRCA1-BARD1 heterodimer coordinates a diverse range of cellular pathways such as DNA damage repair, ubiquitination and transcriptional regulation to maintain genomic stability. BRCA1 acts by mediating ubiquitin E3 ligase activity that is required for its tumor suppressor function. BRCA1 plays a central role in DNA repair by facilitating cellular response to DNA repair. BRCA1 is required for appropriate cell cycle arrests after ionizing irradiation in both the S-phase and the G2 phase of the cell cycle. BRCA1 is involved in transcriptional regulation of P21 in response to DNA damage. BRCA1 is also required for FANCD2 targeting to sites of DNA damage.It may function as a transcriptional regulator. BRCA1 inhibits lipid synthesis by binding to inactive phosphorylated ACACA and preventing its dephosphorylation.
Alternative Names
BRCAI
BRCC1
IRIS
PSCP
RNF53
PNCA4
BROVCA1
PPP1R53
Molecular Weight(MW) 76kDa
Sequence 680 amino acids

BRCA1 antibodyDatabase Links

Entrez Gene 672
SwissProt ID P38398
Protein Accession NP_009229

BRCA1 antibodyApplication

  • Western blot

    0.2-1 ug/ml
    ELISA Titer: 1:1562500
    Positive Control: ACHN cell lysate

Additional Information

Form Liquid
Storage Instructions Aliquot and store at -20°C. Avoid repeated freeze / thaw cycles
Storage Buffer phosphate buffered saline , pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.

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