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EAP30 antibody

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产品名称: EAP30 antibody
产品型号:
产品展商: immunoclone
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简单介绍

EAP30 antibody迅速增长的产品线包括一抗、二抗、**测定及细胞检测试剂盒、蛋白/多肽、激动剂/拮抗剂/活化剂/抑制剂及裂解物等。EAP30 antibody严格的质量控制和验证实验包括各种不同的应用：WB、细胞**荧光、**组化、流式细胞术、ELISA、CHIP、IP和peptide array。


EAP30 antibody  的详细介绍

EAP30 antibodyProduct Profile

Product Name Rabbit anti-EAP30 polyclonal antibody - N-terminal region
Antibody Type Primary Antibodies
Immunogen 
The immunogen for anti-EAP30 antibody: synthetic peptide directed towards the N terminal of human EAP30

EAP30 antibodyKey Feature

Clonality Polyclonal
Isotype IgG
Host Species Rabbit
Tested Applications

WBIHC

Species Reactivity

BovineDogHumanMouseRatZebra Fish

Concentration 1mg/ml
Purification Affinity purified

EAP30 antibodyTarget Information

Gene Symbol EAP30
Gene Synonyms
Dot3
EAP30
VPS22
Gene Full Name SNF8, ESCRT-II complex subunit, homolog (S. cerevisiae)
Gene Summary
ELL encodes an RNA polymerase II transcription factor that undergoes frequent translocation in acute myeloid leukemia (AML). In addition to its elongation activity, ELL contains a novel type of RNA polymerase II interaction domain that is capable of repressing polymerase activity in promoter-specific transcription. EAP30 is a subunit of the ELL complex. EAP30 can interact with ELL and derepress ELL's inhibitory activity in vitro.SNF8, VPS25 (MIM 610907), and VPS36 (MIM 610903) form ESCRT-II (endosomal sorting complex required for transport II), a complex involved in endocytosis of ubiquitinated membrane proteins. SNF8, VPS25, and VPS36 are also associated in a multiprotein complex with RNA polymerase II elongation factor (ELL; MIM 600284) (Slagsvold et al., 2005 [PubMed 15755741]; Kamura et al., 2001 [PubMed 11278625]).[supplied by OMIM].
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Alternative Names
Dot3
EAP30
VPS22
Molecular Weight(MW) 29kDa
Sequence 258 amino acids

EAP30 antibodyDatabase Links

Entrez Gene 11267
SwissProt ID Q96H20
Protein Accession NP_009172

EAP30 antibodyApplication

  • Immunohistochemical

    Human Spleen

  • Immunohistochemical

    Human Heart

  • Western blot

    5.0ug/ml
    Positive Control: HepG2 cell lysate

Additional Information

Form Liquid
Storage Instructions Aliquot and store at -20°C. Avoid repeated freeze / thaw cycles
Storage Buffer phosphate buffered saline , pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.

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