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AIRE antibody

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产品名称: AIRE antibody
产品型号:
产品展商: immunoclone
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简单介绍

AIRE antibody迅速增长的产品线包括一抗、二抗、**测定及细胞检测试剂盒、蛋白/多肽、激动剂/拮抗剂/活化剂/抑制剂及裂解物等。AIRE antibody严格的质量控制和验证实验包括各种不同的应用：WB、细胞**荧光、**组化、流式细胞术、ELISA、CHIP、IP和peptide array。


AIRE antibody  的详细介绍

AIRE antibodyProduct Profile

Product Name Rabbit anti-AIRE polyclonal antibody - middle region
Antibody Type Primary Antibodies
Immunogen 
The immunogen for anti-AIRE antibody: synthetic peptide directed towards the middle region of human AIRE

AIRE antibodyKey Feature

Clonality Polyclonal
Isotype IgG
Host Species Rabbit
Tested Applications

WB

Species Reactivity

Guinea PigHorseHuman

Concentration 1mg/ml
Purification Affinity purified

AIRE antibodyTarget Information

Gene Symbol AIRE
Gene Synonyms
AIRE1
APECED
APS1
APSI
PGA1
Gene Full Name Autoimmune regulator
Gene Summary
The function of the protein encoded by the AIRE gene is not well defined. However it contains zinc finger motifs suggestive of a transcription factor. The protein (isoform 1) is localized to both the nucleus and cytoplasm. Defects in this gene cause the autosomal-recessive systemic autoimmune disease termed autoimmune polyendocrinopathy-candidiasis-ectodermal dystrophy (APECED).This gene encodes a transcriptional regulator that forms nuclear bodies and interacts with the transcriptional coactivator CBP. At least three splice variant mRNAs products have been described including one which results in a premature stop codon and a transcript predicted to be a candidate for nuclear-mediated decay (NMD). Defects in this gene cause the rare autosomal-recessive systemic autoimmune disease termed autoimmune polyendocrinopathy-candidiasis-ectodermal dystrophy (APECED).
Alternative Names
AIRE1
APECED
APS1
APSI
PGA1
Molecular Weight(MW) 58kDa
Sequence 545 amino acids

AIRE antibodyDatabase Links

Entrez Gene 326
SwissProt ID O43918
Protein Accession NP_000374

AIRE antibodyApplication

  • Western blot

    0.2-1 ug/ml
    ELISA Titer: 1:62500
    Positive Control: Human Placenta

Additional Information

Form Liquid
Storage Instructions Aliquot and store at -20°C. Avoid repeated freeze / thaw cycles
Storage Buffer phosphate buffered saline , pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.

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