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p-c-Myc Antibody

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产品名称: p-c-Myc Antibody
产品型号:
产品展商: immunoclone
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简单介绍

p-c-Myc Antibody迅速增长的产品线包括一抗、二抗、**测定及细胞检测试剂盒、蛋白/多肽、激动剂/拮抗剂/活化剂/抑制剂及裂解物等。p-c-Myc Antibody严格的质量控制和验证实验包括各种不同的应用：WB、细胞**荧光、**组化、流式细胞术、ELISA、CHIP、IP和peptide array。


p-c-Myc Antibody  的详细介绍

p-c-Myc AntibodyProduct Profile

Product Name p-c-Myc Antibody (Ser 373)
Antibody Type Tags Antibodies
Modification Notes c-Myc-, N-Myc- and L-Myc-encoded proteins function in cell proliferation, differentiation and neoplastic disease. Myc proteins are nuclear proteins with relatively short half lives. Amplification of the c-Myc gene has been found in several types of human tumors including lung, breast and colon carcinomas, while the N-Myc gene has been found amplified in neuroblastomas. The L-Myc gene has been reported to be amplified and expressed at high level in human small cell lung carcinomas. The presence of three sequence motifs in the c-Myc COOH terminus, including the leucine zipper, the helix-loop-helix and a basic region provided initial evidence for a sequence-specific binding function. A basic region helix-loop-helix leucine zipper motif (bHLH-Zip) protein, designated Max, specifically associates with c-Myc, N-Myc and L-Myc proteins. The Myc-Max complex binds to DNA in a sequence-specific manner under conditions where neither Max nor Myc exhibit appreciable binding. Max can also form heterodimers with at least two additional bHLH-Zip proteins, Mad and Mxi1, and Mad-Max dimers have been shown to repress transcription through interaction with mSin3.

p-c-Myc AntibodyKey Feature

Clonality Polyclonal
Isotype IgG
Host Species Rabbit
Tested Applications

IFIHC

recommended for detection of Ser 373 phosphorylated c-Myc of mouse, rat and human origin by IF and IHC(P):
Species Reactivity

HumanMouseRat

Concentration 100 µg/ml
Purification Affinity purified

p-c-Myc AntibodyTarget Information

Alternative Names
epitope corresponding to phosphorylated Ser 373 of c-Myc of human origin
Tissue Specificity epitope corresponding to phosphorylated Ser 373 of c-Myc of human origin

p-c-Myc AntibodyDatabase Links

Entrez Gene 4609

p-c-Myc AntibodyApplication

  • Application

    Immunoperoxidase staining of formalin-fixed, paraffin-embedded human breast carcinoma tissue showing nuclear staining.

Application Notes
recommended for detection of Ser 373 phosphorylated c-Myc of mouse, rat and human origin by IF and IHC(P):

Additional Information

Form Liquid
Storage Instructions For short-term storage, store at 4° C. For long-term storage, aliquot and store at -20ºC or below. Avoid multiple freeze-thaw cycles.
Storage Buffer phosphate buffered saline , pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.

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