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p53 (phospho Thr387) Antibody

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产品名称: p53 (phospho Thr387) Antibody
产品型号:
产品展商: immunoclone
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简单介绍

p53 (phospho Thr387) Antibody迅速增长的产品线包括一抗、二抗、**测定及细胞检测试剂盒、蛋白/多肽、激动剂/拮抗剂/活化剂/抑制剂及裂解物等。p53 (phospho Thr387) Antibody严格的质量控制和验证实验包括各种不同的应用：WB、细胞**荧光、**组化、流式细胞术、ELISA、CHIP、IP和peptide array。


p53 (phospho Thr387) Antibody  的详细介绍

p53 (phospho Thr387) AntibodyProduct Profile

Product Name p53 (phospho Thr387) Antibody
Antibody Type Primary Antibodies
Product description 
					

						Acts as a tumor suppressor in many tumor types; induces growth arrest or apoptosis depending on the physiological circumstances and cell type. Involved in cell cycle regulation as a trans-activator that acts to negatively regulate cell division by controlling a set of genes required for this process. One of the activated genes is an inhibitor of cyclin-dependent kinases. Apoptosis induction seems to be mediated either by stimulation of BAX and FAS antigen expression, or by repression of Bcl-2 expression. Implicated in Notch signaling cross-over.1) Zakut-Houri R., EMBO J. 4:1251-1255(1985).
					

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Immunogen 
p53 (phospho Thr387) antibody was raised against a peptide sequence around phosphorylation site of threonine 387 (F-K-T (p)-E-G) derived from Human p53.

p53 (phospho Thr387) AntibodyKey Feature

Clonality Polyclonal
Isotype IgG
Host Species Rabbit
Tested Applications

IHC

Species Reactivity

Human

Concentration 1mg/ml
Purification Affinity purified

p53 (phospho Thr387) AntibodyTarget Information

Gene Symbol TP53
Alternative Names
TP53
tumor protein p53
Tumor suppressor p53
Molecular Weight(MW) 43 kDa
Tissue Specificity The antibody detects endogenous levels of p53 only when phosphorylated at threonine 387.

p53 (phospho Thr387) AntibodyDatabase Links

Entrez Gene 7157
Protein Accession NP_000537.3

p53 (phospho Thr387) AntibodyApplication

  • Application

    Immunohistochemical analysis of paraffin-embedded human breast carcinoma tissue using p53 (Phospho-Thr387) antibody (left) or the same antibody preincubated with blocking peptide (right).

Additional Information

Form Liquid
Storage Instructions Store antibody at -20˚C for up to one year.
Storage Buffer Antibody supplied in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.

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