Acts as a tumor suppressor in many tumor types; induces growth arrest or apoptosis depending on the physiological circumstances and cell type. Involved in cell cycle regulation as a trans-activator that acts to negatively regulate cell division by controlling a set of genes required for this process. One of the activated genes is an inhibitor of cyclin-dependent kinases. Apoptosis induction seems to be mediated either by stimulation of BAX and FAS antigen expression, or by repression of Bcl-2 expression. Implicated in Notch signaling cross-over.1) Lin T, et al. (2005) Nat Cell Biol; 7 (2): 165-71. Vega FM, et al. (2004) Mol Cell Biol; 24 (23): 10366-80. Li J, et al. (2004) J Biol Chem; 279 (40): 41275-9. Wang J, et al. (2004) J Biol Chem; 279 (38): 39584-92. More
p53 (Phospho-Ser6) antibody was raised against a peptide sequence around phosphorylation site of serine 6 (P-Q-S (p) -D-P) derived from Human p53.
IHCWB
HumanMouse
Immunohistochemical analysis of paraffin-embedded human breast carcinoma tissue using p53 (Phospho-Ser6).
Western blot analysis of lysed extracts from HT29 and HeLa cells untreated or treated with UV using p53 (Phospho-Ser6).
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