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p53 (phospho Ser392) Antibody

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产品名称: p53 (phospho Ser392) Antibody
产品型号:
产品展商: immunoclone
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简单介绍

p53 (phospho Ser392) Antibody迅速增长的产品线包括一抗、二抗、**测定及细胞检测试剂盒、蛋白/多肽、激动剂/拮抗剂/活化剂/抑制剂及裂解物等。p53 (phospho Ser392) Antibody严格的质量控制和验证实验包括各种不同的应用：WB、细胞**荧光、**组化、流式细胞术、ELISA、CHIP、IP和peptide array。


p53 (phospho Ser392) Antibody  的详细介绍


p53 (phospho Ser392) AntibodyProduct Profile

Product Name p53 (phospho Ser392) Antibody
Antibody Type Primary Antibodies
Product description 
				

					Acts as a tumor suppressor in many tumor types; induces growth arrest or apoptosis depending on the physiological circumstances and cell type. Involved in cell cycle regulation as a trans-activator that acts to negatively regulate cell division by controlling a set of genes required for this process. One of the activated genes is an inhibitor of cyclin-dependent kinases. Apoptosis induction seems to be mediated either by stimulation of BAX and FAS antigen expression, or by repression of Bcl-2 expression. Implicated in Notch signaling cross-over.1) Choi DW, et al. (2013) Mol Cell 51, 374-85
				

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Immunogen 
p53 (phospho Ser392) antibody was raised against a peptide sequence around phosphorylation site of serine 392 (P-D-S (p)-D) derived from Human p53.

p53 (phospho Ser392) AntibodyKey Feature

Clonality Polyclonal
Isotype IgG
Host Species Rabbit
Tested Applications

WB

Western Blot: 1:500~1:1000:
Species Reactivity

Human

Concentration 1mg/ml
Purification Affinity purified

p53 (phospho Ser392) AntibodyTarget Information

Gene Symbol TP53
Alternative Names
Antigen NY-CO-13
Cellular tumor antigen p53
Phosphoprotein p53
TP53
Tumor suppressor p53
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Molecular Weight(MW) 53 kDa
Tissue Specificity The antibody detects endogenous level of p53 only when phosphorylated at serine 392.

p53 (phospho Ser392) AntibodyDatabase Links

Entrez Gene 7157
Protein Accession NP_000537.3

p53 (phospho Ser392) AntibodyApplication

  • Application

    Western blot analysis of extracts from 293 cells treated with Etoposide using Phospho-p53 (Ser392) Antibody. The lane on the right is treated with the antigen-specific peptide.

Application Notes
Western Blot: 1:500~1:1000:

Additional Information

Form Liquid
Storage Instructions Store antibody at -20˚C for up to one year.
Storage Buffer Antibody supplied in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.


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