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Tau (phospho Thr231) Antibody

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产品名称: Tau (phospho Thr231) Antibody
产品型号:
产品展商: immunoclone
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简单介绍

Tau (phospho Thr231) Antibody迅速增长的产品线包括一抗、二抗、**测定及细胞检测试剂盒、蛋白/多肽、激动剂/拮抗剂/活化剂/抑制剂及裂解物等。Tau (phospho Thr231) Antibody严格的质量控制和验证实验包括各种不同的应用：WB、细胞**荧光、**组化、流式细胞术、ELISA、CHIP、IP和peptide array。


Tau (phospho Thr231) Antibody  的详细介绍


Tau (phospho Thr231) AntibodyProduct Profile

Product Name Tau (phospho Thr231) Antibody
Antibody Type Primary Antibodies
Product description 
				

					Promotes microtubule assembly and stability, and might be involved in the establishment and maintenance of neuronal polarity. The C-terminus binds axonal microtubules while the N-terminus binds neural plasma membrane components, suggesting that tau functions as a linker protein between both. Axonal polarity is predetermined by tau localization (in the neuronal cell) in the domain of the cell body defined by the centrosome. The short isoforms allow plasticity of the cytoskeleton whereas the longer isoforms may preferentially play a role in its stabilization.1) Yen S. H. et. al. (1997) Neurochem. 69:1709-1719. Beausoleil S. A. et. al. (2004) Proc. Natl. Acad. Sci. U. S. A. 101:12130-12135. Wintjens R. et. al. (2001) Biol. Chem. 276:25150-25156. Babu J. R. et. al. (2005) Neurochem. 94:192-203. Goedert M., Spillantini M. G. (2000) Biochim. Biophys. Acta 1502:110-121.
				

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Immunogen 
Tau (Phospho-Thr231) antibody was raised against a peptide sequence around phosphorylation site of threonine 231 (V-R-T (p) -P-P) derived from Human Tau.

Tau (phospho Thr231) AntibodyKey Feature

Clonality Polyclonal
Host Species Rabbit
Species Reactivity

Human

Concentration 1mg/ml
Purification Affinity purified

Tau (phospho Thr231) AntibodyTarget Information

Gene Symbol MAPT
Alternative Names
TAU
MSTD
PPND
DDPAC
MAPTL
MTBT1
MTBT2
FTDP-17
CREB2
CREBP1
MAPT
MTAPT
Neurofibrillary tangle protein
PHF-tau
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Molecular Weight(MW) 48, 62, 78 kDa
Tissue Specificity This antibody detects endogenous level of Tau only when phosphorylated at threonine 231.

Tau (phospho Thr231) AntibodyDatabase Links

Entrez Gene 4137
Protein Accession NP_001116538.1

Tau (phospho Thr231) AntibodyApplication

  • Application

    Western blot analysis of lysed extracts from mouse brain tissue using Tau (Phospho-Thr231).

  • Application

    Immunohistochemical analysis of paraffin-embedded rat hippocampal region tissue from a model with Alzheimer’s Disease using Tau (Phospho-Thr231).

Application Notes
Western Blot: 1:500~1:1000, Immunohistochemistry: 1:50~1:100:

Additional Information

Form Liquid
Storage Instructions Store antibody at -20˚C for up to one year.
Storage Buffer Antibody supplied in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.


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