Promotes microtubule assembly and stability, and might be involved in the establishment and maintenance of neuronal polarity. The C-terminus binds axonal microtubules while the N-terminus binds neural plasma membrane components, suggesting that tau functions as a linker protein between both. Axonal polarity is predetermined by tau localization (in the neuronal cell) in the domain of the cell body defined by the centrosome. The short isoforms allow plasticity of the cytoskeleton whereas the longer isoforms may preferentially play a role in its stabilization.1) Li G, Yin H, et. al . (2004) J Biol Chem ; 279 (16): 15938-45. Noble W, et al. (2003) Neuron ; 38 (4): 555-65. Giasson BI, et al. (2002) . Biochemistry; 41 (51): 15376-87. Lee G., et. al. (1989) . Neuron 2:1615-1624. Andreadis A. et. al. (1992) Biochemistry 31:10626-10633. More
Tau (Phospho-Ser404) antibody was raised against a peptide sequence around phosphorylation site of serine 404 (D-T-S (p) -P-R) derived from Human Tau.
IFIHCWB
HumanMouseRat
Western blot analysis of lysed extracts from mouse brain tissue using Tau (Phospho-Ser404).
Top Image: Immunohistochemical analysis of paraffin-embedded rat hippocampal region tissue from a model with Alzheimer’s Disease using Tau (Phospho-Ser404). Bottom Image: Immunofluorescence staining of methanol-fixed HeLa cells using Tau (Phospho-Ser404).
沪公网安备 31011702004356号
