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EGFR Antibody

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产品名称: EGFR Antibody
产品型号:
产品展商: immunoclone
产品文档: 无相关文档

简单介绍

EGFR Antibody迅速增长的产品线包括一抗、二抗、**测定及细胞检测试剂盒、蛋白/多肽、激动剂/拮抗剂/活化剂/抑制剂及裂解物等。EGFR Antibody严格的质量控制和验证实验包括各种不同的应用：WB、细胞**荧光、**组化、流式细胞术、ELISA、CHIP、IP和peptide array。


EGFR Antibody  的详细介绍

EGFR AntibodyProduct Profile

Product Name EGFR Antibody
Antibody Type Primary Antibodies
Product description 
					

						EGFR is a transmembrane glycoprotein that is a member of a family of protein tyrosine kinases crucial in maintaining a normal balance in cell growth and development. A prototype member of the type 1 receptor tyrosine kinases, EGFR is encoded by the cellular oncogene cerbB1. EGFR has an extracellular ligand binding domain, a single transmembrane region, and cytoplasmic domain which is composed of a tyrosine kinase domain and a carboxy terminal domain. The carboxy terminal domain contains at least four tyrosine autophosphorylation sites. Increased production or activation of EGFR has been associated with poor prognosis in a variety of tumors. EGFR overexpression is observed in tumors of the head and neck, brain, bladder, stomach, breast, lung, endometrium, cervix, vulva, ovary, esophagus, stomach and in squamous cell carcinoma.1) Aifa, S., et al., Exp. Cell Res. 302(1):108-114 (2005).
					

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Immunogen 
This EGFR antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 956-985 amino acids from human EGFR.

EGFR AntibodyKey Feature

Clonality Polyclonal
Isotype Ig
Host Species Rabbit
Tested Applications

WB

For WB starting dilution is: 1:1000:
Species Reactivity

Human

Concentration 1mg/ml
Purification Affinity purified

EGFR AntibodyTarget Information

Gene Symbol EGFR
Alternative Names
Epidermal growth factor receptor
Proto-oncogene c-ErbB-1
Receptor tyrosine-protein kinase erbB-1
EGFR
ERBB
ERBB1
HER1
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Molecular Weight(MW) 134 kDa
Sequence Similarities Predicted species reactivity based on immunogen sequence: Mouse

EGFR AntibodyDatabase Links

Entrez Gene 1956
Protein Accession P00533

EGFR AntibodyApplication

  • Application

    Western blot analysis of EGFR using rabbit polyclonal EGFR Antibody.293 cell lysates (2 ug/lane) either nontransfected (Lane 1) or transiently transfected with the EGFR gene (Lane 2).

Application Notes
For WB starting dilution is: 1:1000:

Additional Information

Form Liquid
Storage Instructions Store at 4˚C for three months and -20˚C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.
Storage Buffer Supplied in PBS with 0.09% (W/V) sodium azide.

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