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14 3 3 zeta (phospho Ser58) Antibody

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产品名称: 14 3 3 zeta (phospho Ser58) Antibody
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产品展商: immunoclone
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简单介绍

14 3 3 zeta (phospho Ser58) Antibody迅速增长的产品线包括一抗、二抗、**测定及细胞检测试剂盒、蛋白/多肽、激动剂/拮抗剂/活化剂/抑制剂及裂解物等。14 3 3 zeta (phospho Ser58) Antibody严格的质量控制和验证实验包括各种不同的应用：WB、细胞**荧光、**组化、流式细胞术、ELISA、CHIP、IP和peptide array。


14 3 3 zeta (phospho Ser58) Antibody  的详细介绍


14 3 3 zeta (phospho Ser58) AntibodyProduct Profile

Product Name 14 3 3 zeta (phospho Ser58) Antibody
Antibody Type Primary Antibodies
Product description 
				

					This gene product belongs to the 14-3-3 family of proteins which mediate signal transduction by binding to phosphoserine-containing proteins. This highly conserved protein family is found in both plants and mammals, and this protein is 99% identical to the mouse, rat and sheep orthologs. The encoded protein interacts with IRS1 protein, suggesting a role in regulating insulin sensitivity. Several transcript variants that differ in the 5' UTR but that encode the same protein have been identified for this gene.1) Gu YM, et al. (2006) FEBS Lett ; 580 (1): 305-310Powell DW, et al. (2003) Mol Cell Biol; 23 (15): 5376-5387Mackintosh C. (2004) Biochem J; 381 (Pt 2): 329-342.
				

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Immunogen 
14-3-3 zeta (Phospho-Ser58) antibody was raised against a peptide sequence around phosphorylation site of serine 58 (R-S-S (p) -W-R) derived from Human 14-3-3 zeta.

14 3 3 zeta (phospho Ser58) AntibodyKey Feature

Clonality Polyclonal
Host Species Rabbit
Species Reactivity

Human

Concentration 1mg/ml
Purification Affinity purified

14 3 3 zeta (phospho Ser58) AntibodyTarget Information

Gene Symbol YWHAZ
Molecular Weight(MW) 28 kDa
Tissue Specificity This antibody detects endogenous level of 14-3-3 zeta only when phosphorylated at serine 58.

14 3 3 zeta (phospho Ser58) AntibodyDatabase Links

Entrez Gene 7534
Protein Accession NP_001129171.1

14 3 3 zeta (phospho Ser58) AntibodyApplication

  • Application

    Western blot analysis of lysed extracts from HeLa cells untreated or treated with UV using 14-3-3 zeta (Phospho-Ser58).

  • Application

    Top Image: Immunohistochemical analysis of paraffin-embedded human breast carcinoma tissue using 14-3-3 zeta (Phospho-Ser58). Bottom Image: Immunofluorescence staining of methanol-fixed HeLa cells using 14-3-3 zeta (Phospho-Ser58).

Application Notes
Western Blot: 1:500~1:1000, Immunohistochemistry: 1:50~1:100, Immunofluorescence: 1:100~1:200:

Additional Information

Form Liquid
Storage Instructions Store antibody at -20˚C for up to one year.
Storage Buffer Antibody supplied in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.


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