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Amyloid Precursor Protein Antibody

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产品名称: Amyloid Precursor Protein Antibody
产品型号:
产品展商: immunoclone
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简单介绍

Amyloid Precursor Protein Antibody迅速增长的产品线包括一抗、二抗、**测定及细胞检测试剂盒、蛋白/多肽、激动剂/拮抗剂/活化剂/抑制剂及裂解物等。Amyloid Precursor Protein Antibody严格的质量控制和验证实验包括各种不同的应用：WB、细胞**荧光、**组化、流式细胞术、ELISA、CHIP、IP和peptide array。


Amyloid Precursor Protein Antibody  的详细介绍

Amyloid Precursor Protein AntibodyProduct Profile

Product Name Amyloid Precursor Protein Antibody
Antibody Type Primary Antibodies
Product description 
					

						A large body of evidence has implicated the amyloid precursor protein (APP) in the pathogenesis of Alzheimer's disease (AD) (Kamenetz et al., 2003). The phosphorylation of APP at Thr668 is thought to play a critical role in generation of the soluble APP (beta) and beta-amyloid peptide (abeta) which are the major components of senile plaques in patient brains inflicted with AD (Liu et al., 2003; Ando et al., 2001).1) Ando K, Iijima KI, Elliott JI, Kirino Y, Suzuki T (2001) Phosphorylation-dependent regulation of the interaction of amyloid precursor protein with Fe65 affects the production of beta-amyloid. J Biol Chem 276:40353-40361.
					

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Immunogen 
Peptide corresponding to amino acid residues from the C-terminal region of rat APP.

Amyloid Precursor Protein AntibodyKey Feature

Clonality Polyclonal
Host Species Rabbit
Tested Applications

WB

The antibody has been directly tested for reactivity in rat tissue. It is anticipated that the antibody will also work with canine, chicken, human, mouse and non-human primate tissues based on the fact that these species have 100% homology with the amino acid sequence used as antigen.:
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Species Reactivity

DogHumanMouseRat

Concentration 1mg/ml
Purification Affinity purified

Amyloid Precursor Protein AntibodyTarget Information

Gene Symbol App
Alternative Names
Abeta
ABPP
APP
Molecular Weight(MW) 115

Amyloid Precursor Protein AntibodyDatabase Links

Entrez Gene 54226
Protein Accession P08592

Amyloid Precursor Protein AntibodyApplication

  • Application

    Western blot of rat hippocampal lysate showing specific immunolabeling of the ~115k APP protein.

Application Notes
The antibody has been directly tested for reactivity in rat tissue. It is anticipated that the antibody will also work with canine, chicken, human, mouse and non-human primate tissues based on the fact that these species have 100% homology with the amino acid sequence used as antigen.:
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Additional Information

Form Liquid
Storage Instructions Amyloid Precursor Protein antibody can be stored at -20˚C and is stable at -20˚C for at least 1 year.
Storage Buffer 100 uL in 10 mM HEPES (pH 7.5), 150 mM NaCl, 100 ug per mL BSA and 50% glycerol.

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