Product Name	MEK1 / MEK2 (phospho Ser217 / Ser221) Antibody
Antibody Type	Primary Antibodies
Product description	Catalyzes the concomitant phosphorylation of a threonine and a tyrosine residue in a Thr-Glu-Tyr sequence located in MAP kinases. Activates ERK1 and ERK2 MAP kinases.1) Shen R, et al. (2002) Mol Cell Biol; 22 (10): 3230-3236Preisinger C, et al. (2005) EMBO J; 24 (4): 753-765Laine P, et al. (2000) Biochem J; 349 (Pt 1): 19-25Yaglom J, et al. (2003) Mol Cell Biol; 23 (11): 3813-3824Dahan S, et al. (2002) Infect Immun; 70 (5): 2304-2310 More
Immunogen	MEK1/MEK2 (Phospho-Ser217/Ser221) antibody was raised against a peptide sequence around phosphorylation site of serine 217/221 (I-D-S (p) -M-A) derived from Human MEK1/MEK2.

Clonality	Polyclonal
Host Species	Rabbit
Tested Applications	IHCWB
	Western Blot: 1:500~1:1000, Immunohistochemistry: 1:50~1:100:
Species Reactivity	HumanMouseRat
Concentration	1mg/ml
Purification	Affinity purified

Gene Symbol	MAP2K1 MAP2K2
Alternative Names	CFC3 MEK1 MKK1 MAPKK1 PRKMK1 ERK activator kinase 1/ERK activator kinase2 MAP kinase kinase 1/MAP kinase kinase 2 MAP2K1/MAP2K1 MAPK/ERK kinase 1/MAPK/ERK kinase 2 MAPKK 1/MAPKK 1 More
Molecular Weight(MW)	45 kDa
Tissue Specificity	This antibody detects endogenous level ofMEK1/MEK2 only when phosphorylated at serine 217/221.

Entrez Gene	5604 / 5605
Protein Accession	NP_002746.1 / NP_109587.1

Application

Immunohistochemical analysis of paraffin-embedded human breast carcinoma tissue using MEK1/MEK2 (Phospho-Ser217/Ser221).
Application

Western blot analysis of lysed extracts from HeLa cell untreated or treated with UV MEK1/MEK2 (Phospho-Ser217/Ser221) Antibody#11205

Application Notes	Western Blot: 1:500~1:1000, Immunohistochemistry: 1:50~1:100:

Form	Liquid
Storage Instructions	Store antibody at -20˚C for up to one year.
Storage Buffer	Antibody supplied in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.